Particle Surface Area As a Dose Metric
Project Information
| Principal Investigator | Vincent Castranova |
| Institution | National Institute for Occupational Safety and Health |
| Project URL | View |
| Relevance to Implications | High |
| Class of Nanomaterial | Engineered Nanomaterials |
| Impact Sector | Human Health |
| Broad Research Categories |
Hazard |
| NNI identifier | b2-7 |
Funding Information
| Country | USA |
| Anticipated Total Funding | $1,000,000.00 |
| Annual Funding | $333,333.33 |
| Funding Source | NIOSH |
| Funding Mechanism | |
| Funding Sector | |
| Start Year | 2004 |
| Anticipated End Year | 2007 |
Abstract/Summary
This project will determine whether the high inflammatory reaction of the lung to ultrafine particles compared to an equal mass of fine particles of similar composition is due to a unique toxic property of ultrafine particles or could be explained by their high surface area, i.e., is particle surface area a more appropriate metric for exposure dose than particle mass? Specific airms are: 1) expose alveolar type II epithelial cells, bronchial epithelial cells, and alveolar macrophages to ultrafine and fine crystalline silica, titanium dioxide or carbon black; determine toxicity on a particle surface area/cell surface area basis; 2) determine if titanium dioxide and carbon black exhibit similar in vitro toxicity on a particle surface area basis while silica exhibits greater toxicity; 3) determine the pulmonary response to inhalation of ultrafine vs. fine titanium dioxide on an equivalent deposited particle surface area/pulmonary epithelial cell surface area basis; 4) provide in vitro and in vivo data to EID for modeling.
(Project budget is an estimate only, based on available data)
